This article makes one think differently. I like articles that challenge common wisdom.
Is Metformin Associated With Lactic Acidosis?
It appears that metformin itself may not increase the risk for lactic acidosis. And although metformin use has increased over the years, the incidence of lactic acidosis has not increased. Additionally, there is no evidence to suggest that sulfonylureas alone increase the risk for lactic acidosis. Rather, the presence of underlying conditions and concomitant use of other medications may elevate an individual's risk level.
Some suggest that diabetes mellitus, rather than specific antidiabetes medications, may predispose a patient to lactic acidosis. The mechanisms for this increased risk are unknown. In practice, it may be important to consider diabetes mellitus as a risk factor for developing lactic acidosis and examine each patient's medication profile as well as other underlying conditions to determine a patient’s overall risk.
Very interesting article that makes me think.
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