17 days at the VA – Day 3

17 Nov
2009

My team had a relatively easy Sunday call day.  On post call days, we spend 3 hours presenting new patients, discussing old patients and seeing all the patients.  I told me team on Sunday that I would use the entire time regardless.  With only 3 new patients, we had leisurely, and I hope educational, discussions of each patient.

One patient in particular presented an interesting issue – why saline can make hyponatremia worse?  Our patient presented with a sodium level of 125.  His serum osms were 249. He is euvolemic.  Prior to receiving the urine osm report, we started IV saline – giving approximately 1.3 liters.  Then the urine osms were approximately 630.

For those who already understand this phenomenon, you might predict that the sodium would further decrease.  Some readers are scratching their heads at this point.  Saline has osms of approximately 300 – so how can IV saline lower the serum sodium.

In fact the serum sodium went down significantly.  Here is the explanation:

Assume 1 liter of saline has 300 mOsm of solute (in this case NaCl).  For calculation ease assume the urine concentration is 600 mOsm/liter.

In order to excrete the 300 mOsm of NaCl with a urine concentration of 600 mOsm/liter, we will only excrete 500 cc of urine.  Thus, we have partitioned the liter of saline into 500 cc of 600 mOsm/L urine and 500 cc of water.

Under conditions of very high urine osms and euvolemia, giving saline actually provides free water to lower the sodium.  Our patient proves the explanation.

If the patient had been volume contracted, saline would have worked perfectly.

Related posts:

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2 Responses to 17 days at the VA – Day 3

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Patrick Baroco

November 17th, 2009 at 9:37 am

What was the cause of the hyponatremia?  Psychogenic polydipsia?

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Anon

November 17th, 2009 at 11:27 pm

Your team had 2 pts before call started and got 3 new pts?  Your post-call service is 5?  Is this an anomaly or is that a normal pt load for a ward team?  Seems like it would be hard to get any patient care experience if you only admit 3 on call and have 5 to round on total.

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