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	<title>Comments on: A rare side effect for bisphosphonates</title>
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	<description>Internal medicine, American health care, and especially medical education</description>
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		<title>By: ba</title>
		<link>http://www.medrants.com/archives/2822/comment-page-1#comment-182230</link>
		<dc:creator>ba</dc:creator>
		<pubDate>Sun, 04 Jun 2006 01:01:17 +0000</pubDate>
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		<description>This makes me more interested in the Japanese&#039; commercial development of vitamin K2, the menaquinone-4  (MK4, menatetrenone) vitamer that has a corresponding transport protein in the human body.  The Japaanese have very interesting results with osteoporosis and liver cancer remissions in 45+ milligrams/day to over 90 mg/d MK4.  (that&#039;s mg, *not* mcg).  Here in the US , the work that suggests using it to keep the calcium in bones instead of migrating to the arteries is also interesting.   Along with mixed tocopherols as &quot;blood thinner&quot;...</description>
		<content:encoded><![CDATA[<p>This makes me more interested in the Japanese&#8217; commercial development of vitamin K2, the menaquinone-4  (MK4, menatetrenone) vitamer that has a corresponding transport protein in the human body.  The Japaanese have very interesting results with osteoporosis and liver cancer remissions in 45+ milligrams/day to over 90 mg/d MK4.  (that&#8217;s mg, *not* mcg).  Here in the US , the work that suggests using it to keep the calcium in bones instead of migrating to the arteries is also interesting.   Along with mixed tocopherols as &#8220;blood thinner&#8221;&#8230;</p>
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		<title>By: ben</title>
		<link>http://www.medrants.com/archives/2822/comment-page-1#comment-181961</link>
		<dc:creator>ben</dc:creator>
		<pubDate>Sat, 03 Jun 2006 20:07:21 +0000</pubDate>
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		<description>Jaw osteonecrosis seem to be a RARE side effect in the context of treatment with biphosphonates in malignancy.
But the rarity of this side effect is definitely overwhelmed by the attention recently given to it by the media.
In a coverage by foxnewstv at the metropolitan washington dc area, late April or early May, a dental surgeon even gave a soundbyte in the report indisinuating how general internists prescribe fosamax left and right - irresponsibly unaware of this side effect. It is rare, in rare settings and should not be irresponsibly sensationalized by doctors whom, as you indicated may have seen it in the teen times, yet became consultants about the condition. This gives more fodder for the litigants who drive up healthcare costs for no productive value to society.</description>
		<content:encoded><![CDATA[<p>Jaw osteonecrosis seem to be a RARE side effect in the context of treatment with biphosphonates in malignancy.<br />
But the rarity of this side effect is definitely overwhelmed by the attention recently given to it by the media.<br />
In a coverage by foxnewstv at the metropolitan washington dc area, late April or early May, a dental surgeon even gave a soundbyte in the report indisinuating how general internists prescribe fosamax left and right &#8211; irresponsibly unaware of this side effect. It is rare, in rare settings and should not be irresponsibly sensationalized by doctors whom, as you indicated may have seen it in the teen times, yet became consultants about the condition. This gives more fodder for the litigants who drive up healthcare costs for no productive value to society.</p>
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