I had a wonderful time last week at the Canadian Society of Internal Medicine meetings. Today I want to share 2 of the things I learned, the first being clinical, the other a more complete understanding of GIM.
COUMADIN GENETICS
Clinically, I heard a wonderful talk about the genetics of coumadin metabolism. Searching the web I found this abstract which is relevant – Genetic variants affect warfarin metabolism
In an article in the April 3, 2002, edition of the Journal of the American Medical Association, Dr. David Veenstra, assistant professor in the UW School of Pharmacy, and his colleagues say that the two genetic variants, CYP2C9*2 and CTP2C9*3, are relatively common. This is one of the first studies to show an association between genetic variants and the risk of a serious adverse drug reaction.
“After we identified these patients’ genotypes, we looked back at their medical records to determine if they had had severe bleeding incidents while they were taking warfarin,†Veenstra said. “We looked at two specific variants in the gene for the enzyme that helps patients metabolize warfarin.â€
Compared to other patients, those with at least one of the genetic variants required more time to achieve stable dosing. In other words, it took a longer period of time to determine an effective and safe dose.
Additionally, patients with at least one of the two genetic variants had a significantly increased occurrence of a serious or life-threatening bleeding incident. Veenstra says that the small numbers of patients (58) with the genetic variants in the 185-person study group suggests caution in interpreting the study’s results — but that screening for these variants may allow clinicians to develop dosing protocols and surveillance techniques to reduce the risk of adverse drug reactions in warfarin patients.
Perhaps many readers already know this. I suspect that in the relatively near future, we will test for genetic variants prior to dosing coumadin!
GIM IN CRISIS
I had much time to talk with many wonderful general internists in Canada. They serve mostly as consultants, both inpatient and outpatient. They have just published a document titled: Care-Fully: Defining a Plan for General Internal Medicine in Canada.
Internal medicine residents in Canada choose subspecialty training in approximately the same numbers as in the US! My discussions helped me understand that the problems of GIM are global. I talked with the President of The Internal Medicine Society of Australia and New Zealand (IMSANZ) . She related the same observations. I also talked with an Irish General Internist – same story.
GIM represents the greatest intellectual challenge in internal medicine. As I pointed out last week, David Sackett writes a clear conceptualization in his introduction to the document:
When encountering patients with undifferentiated or multi-system disease, general internists excel at “sorting out” their illnesses and balancing the management of multi-system disease. They are particularly skilled in the evaluation and care of such patients when they are acutely and severely ill. This is in contrast to subspecialists who, by focusing on deeper but narrower aspects of single-system disease, are more comfortable practicing in a “rule-out” mode, and often are uncomfortable with sick patients whose illnesses are multi-system or arise from another system (e.g., undifferentiated shock).
I believe that while finances drive residents towards sub-specialties, so does the breadth of GIM. I have had more than one resident tell me that GIM is too difficult. We accept the most uncertainty, and the greatest intellectual challenge. We also accept the patients that everyone else refuses. I thought this was a local phenomenon, but I have learned that it is global.
We should celebrate GIM. Making it exciting for students and residents is our greatest challenge, but one that I believe we must meet.
Thanks to CSIM for their wonderful hospitality. I look forward to working with them in the future.
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{ 1 comment… read it below or add one }
Dear Dr Crestor
Your comments above appreciated. Below is an editorial in the making: does this make sense south of the border?
________________________________________________________
Editorial CSIM Journal
Image and Identity: the Internist’s lodestone
A senior colleague of mine gave me an historical perspective on the role of the internal medicine ’specialist.
“You know, when I trained, at the Montreal General, there was little one could do by way of diagnostic studies. We could take x-rays, and look at blood, urine, and tissue. But there was no ultrasound, or CT or fancy angiography. One lady I remember was deeply jaundiced. We had her in hospital for 3 weeks. She went for her laparotomy to confirm pancreatic cancer. When doctors were stumped, they sought out the advice of a diagnostician, someone with a lot of experience, who kept up with the literature, and who could shed light on a complex problem. An internist. Now, the the practice of Medicine has changed. We diagnose people antemortem, hence the fall in number of PMs. We have most of the answers for most of the diagnostic problems. Just as radiology has changed, therapeutics have changed. At a time when my boss recommended antiserum for pneumococcal sepsis, the young bucks said this sulpha drug worked like a damn.
And what about home visits? We used to make these but not now. The role of the visiting specialist was to tell the family that this was a very serious disease, that we couldn’t do much by way of therapy, and to expect the worst in a given period of time. The family were accepting, and could then prepare for the worst with some degree of certainty. That is what they needed at that timeâ€.
If Internal Medicine has changed, should we change with it? When Olser, in an address to the American Association of Physicians in 1895, called for training of “able young men…. in internal medicine as a specialtyâ€, he created a name that confused the layman and the practitioner alike. How could a generalist be a specialist too?
As the volume of knowledge grew, and the capacity for internists to know everything and do everything receded, subspecialist departments expanded in number and in power. Procedural skills took precedence over cognitive skills, leading to a shortfall in recognition and reward. Internists do many procedures, but none are unique to GIM, nor well paid.
GIM has changed. From a mother-like core-discipline encompassing all of the subspecialties, GIM now focuses on the care of patients with multisystem problems, on multiple drugs. Patients with diabetes and hypertension, with shortness of breath and chest pain, with atrial fibrillation and stroke. We treat medical complications of pregnancy and the degenerative diseases of ageing. GIMS have a strong sense of responsibility for those who have social problems, or ethical issues. Ours is a discipline embracing teaching, research, administration and healthcare planning.
Residents attending the GIM workshops in Toronto last November had interesting feedback for us. “I can get 2 fellowships in 5 years of training, so why just settle for just GIM?â€. “I can make more money with a better lifestyle by choosing a subspecialtyâ€. Clearly, residents perception of GIM is influenced by the image of the overworked, undervalued and underpaid tertiary centre generalist, taking over patients the ‘subspecialists have finished with’, fighting to get patients placed when beds are at a premium, managing complex problems that may need attention at unsocial hours. An afternoon devoted to discussing the broad tapestry of GIM did little to change these residents’ minds.
The name ‘internist’ is confusing. We are not interns. In general, we do not do internal examinations (unless indicated). Most of the diseases we treat have internal manifestations, but why define them by location in the first place? I believe it is time for GIM to redefine itself, so that both students of Medicine, patients, politicians, and our fellow physicians can better comprehend the breadth and scope of what we do.
What term best describes the 21st century generalist? In the US, where internists have a more primary care role, “Doctors for Adults†is a term promoted by ACP. In Canada, where a consultant role is still prevalent, “Specialists in Complex Adult Medicine†may be more appropriate.
If image and identity are to be our downfall, in times of exploding demand and withering recruitment, let’s find out what the market understands, and invest in a PR strategy that will help all of us appreciate our true worth. Stop talking about a name change and enact one. Sell generalism as well as the partialists do their domain. Recruitment often follows income, and it is time cognitive skills were adequately rewarded. We need GIM to flourish, not just for our own benefit, but for the functional survival of our surgeons, anesthetists, GPs, healthcare planners – and patients – alike.
Hector M Baillie MD
Specialist in Complex Adult Medicine
Secretary, CSIM