On Oxycontin

by rcentor on September 11, 2003

Panel Rejects Pleas to Curb Sales of a Widely Abused Painkiller

Federal drug advisory panel yesterday rejected pleas from members of Congress and drug enforcement officials that sales of the widely abused painkiller OxyContin be severely restricted.

But officials from the Bush administration told the panel they were seriously considering even broader rules requiring doctors to get special training before being allowed to prescribe OxyContin or any other controlled narcotic. The changes are intended to stem a growing tide of prescription drug abuse.

OxyContin is responsible for 500 to 1,000 deaths a year, a panel member estimated yesterday. Some two million people used narcotics recreationally in 2001, the last year for which figures were available, up from 1.5 million in 1998 and 400,000 in the mid-1980′s, according to data presented to the panel.

Introduced in 1995, OxyContin is a pill that gradually releases steady amounts of narcotics for 12 hours. Before OxyContin, patients were required to take pills every four hours to achieve significant pain relief. By crushing OxyContin pills, drug abusers can get the full, 12-hour narcotic effect almost immediately. Snorting or injecting the crushed pill can lead to overdose and death.

Some panel members suggested that the death rate could swell substantially if Purdue Pharma, the maker of OxyContin, was allowed to sell Palladone, a new, more powerful painkiller that Purdue has asked the Food and Drug Administration to approve for sale. Most panel members, however, gave tepid support to Purdue’s plan to introduce Palladone slowly. Several suggested the drug’s initial introduction period should be extended to a year from the company’s proposed four months.

The active ingredient in Palladone is identical to that in Dilaudid, “the drug of choice for addicts,” said Laura Nagel, deputy assistant administrator of the Drug Enforcement Administration’s office of diversion control, who participated in the panel discussions.

Wow! Let me frame the debate. What is more important? Should we have a great option for pain relief – especially for those with chronic pain? Should we have a valuable option for palliative care? Do these concerns outweigh the abuse concerns?

Kudos to the committee for worrying more about the deserving patients. Maybe this committee could consider medical marijuana.

The panel and the Bush administration do want physicians to use these drugs more intelligently.

Under the administration’s proposal, doctors would have to prove that they had taken a painkiller class before receiving permission from the Drug Enforcement Administration to prescribe controlled narcotics. Such permission is now granted routinely without special training. The agency requires that doctors register for this permission every three years, and under the administration’s proposal, the agency would require that doctors undergo refresher training every three years.

“We should restrict the prescriptions of these drugs to the educated physicians,” said Dr. Carol Rose, a panel member and an anesthesiologist from Presbyterian University Hospital in Pittsburgh.

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{ 2 comments }

R.G. Lacsamana September 11, 2003 at 10:17 am

For the vast majority of physicians who have been prescribing narcotics, including
Oxycontin, in the proper manner, the vote by the advisory drug panel to reject placing more restrictions should be a welcome one. It makes no sense to place shackles on physicians when it appears only a minusucule number of them are abusing their prescribing privileges.

I don’t have any problem, however, of requiring physicians to take a course on the proper ways of prescribing narcotics.
Over the years, as a condition of renewing our licenses, we have been required to take courses on AIDS, domestic violence, and prevention of medical errors, among other things. Pain management should be no different from these other classes.

Along with this new proposal, pharmacists ought to be more vigilant in detecting and reporting unusual and fraudulent prescribing habits of physicians, in coordination with state licensing boards to ensure that those who abuse their privileges should be dealt with harshly, including suspension of their licenses. Pain management clinics, which have blossomed over the past few years, also require more scrutiny and supervision.

A systematic approach involving coordination of efforts from many elements, rather than a fiat with restrictions, would be a much better step to stem a growing tide of drug abuse and deaths.

Stephen Payson September 24, 2003 at 1:12 pm

Hillbilly Heroin
What has been a very successful product for the treatment of cancer pain and for the treatment of severe intractable chronic pain as been a disaster for the Drug Abuse Prevention Community of Eastern Kentucky. Science based Drug Abuse Prevention is based on two pillars.
1. Environmental prevention.
2. Recognition of true peer attitudes and wise decision-making.
Environmental prevention is based on making drugs of abuse hard to secure. The State of Kentucky spends hundreds of thousands of dollars each year keeping tobacco out the hands of citizens below the age of 18 and alcohol away from citizen below the age of 21.
The state does this because:
1. The earlier in life an adolescent uses drugs, the greater the chance of abuse patterns developing – followed by addiction.
2. The greater the amounts and frequency of adolescent drug use, the greater the chance of abuse patterns developing – followed by addiction.
The federal government spends millions of dollars to limit the amount of heroin, cocaine and marijuana brought into this country each year. The thought is the less drugs available the less the frequency of use and the volume of drug use. The less the frequency/volume of drug use the less likely hood of addiction.
How are we doing with our environmental prevention in Eastern Kentucky?

A recent KIP Student Survey of the Pike County Schools in KY shows that when asked how many students had taken prescription drugs or narcotics without a doctor telling them to in the past 30 days: 10% of the 8th graders, 20% of the 10th graders and 26% of the 12th graders reported using. 2% of the 6th graders, 6% of the 8th graders, 9% of the 10th graders and 11% of the 12th graders reported they thought they had a drinking or drug problem.

I would summit that the environment of Eastern Kentucky is, at the present time, polluted with legally manufactured synthetic opioids. The drug of choice is clearly OxyContin, a time-release formulation of oxycodone. The problem has been caused by a multitude factors among which are:
Problem One:
The way in which adolescents and laypersons view OxyContin. OxyContin’s use and abuse has been widely covered by the news media. This drug is perceived as the badest of the bad, the real thing, the highest of highs. Youth in open rebellion or drug seeking individuals fine the press coverage titillating and act by seeking out this drug and paying top dollar for it.

Problem Two:
The false idea that this narcotic is truly a “safe” agent for the control of moderate chronic pain. It is true, that if used as directed, OxyContin has a lower addiction potential than other opioids because of the formulation but this drug is no magic bullet. Other effective drugs, such as amphetamine inhalers and Talwin, were safe and effective if used as directed but when misused were considered a threat to public health and therefore were pulled from the market or modified. The idea that OxyContin is a safe and effective pain killer with no down side has been sold to the physicians and pharmacists all over this country and has lead to mass over prescribing of this agent. The downside of this narcotic is its abuse potential when misused. Sales of OxyContin have increased from 55 million dollars in 1996 to 1.14 billion dollars in 2000. This represents a 21-fold increase in the number of tablets sold. This in turn has led to the overwhelming amount of the drug being diverted for street use. The question is: has the amount of cancer pain and severe intractable chronic pain increased 21 fold in this country in the last 5 years? It is plain that an increased amount of the drug on the street is directly related to the increased number poor judgment prescriptions being written.
Problem Three:
Most of Eastern Kentucky is located in the geo -economic area known as the Distressed Counties of Appalachia. 1/3 of the population lives below the poverty level. This makes drug diversion a real problem. A 30-day supply of OxyContin (60 mg, 1 every 12 hours) makes a one-month OxyContin prescription worth $4800 on the street. This is real money for someone who lives below the poverty line and adds to the diversion potential for this drug in our area.
The OxyContin environmental pollution of Eastern Kentucky must be stopped. The amount of OxyContin on the street must be reduced. This can only come about with stricter control and less substance available.

The individuals who become addicted to narcotics because of this pollution must be helped. We have no adolescent treatment beds available in our area and state wide there are waiting lists. The war on drugs is the only war in which we send the victims to jail. There will be far-reaching environmental impacts from this substance long after the drug is gone or has been reformulated.

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