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August 30, 2002


OTC or not

The good and bad of going over-the-counter Physicians often have mixed feelings about drugs going OTC. This article gives a nice balance and puts the decision into appropriate perspective. I will briefly discuss 2 drug classes.

Women can now self treat for candida vaginitis. Most women know when they have it, and the treatment usually works well. However, other infections can cause vaginitis. Some vaginitis is not infectious. So some women will waste money and time by self treating incorrectly.

Proton pump inihibitors (Prilosec, Prevacid, Aciphex and the hated Nexium) are a class of drugs which inhibit acid secretion in the stomach. The give relief to ulcers, simple gastritis, and most important GERD (gastroesophageal reflux disease - known to most as the disease associated with heartburn). We already have the histamine 2 blockers OTC (Tagament, Pepcid, Zantac) for these conditions. PPIs work better. So what is my concern? Heartburn or abdominal pain may herald a more serious condition. I believe that my history taking would give me some clues to evaluating some patients further. Gastroenterologists see the worse cases of GERD - which often have complications like stricture or even cancer. If patients self treat for years, they may miss the opportunity for better diagnosis and treatment. On the other hand, OTC equals lower prices for PPIs. The article gives the right balance. I do want OTC Prilosec, but I want patients to still talk to me about the problem periodically.

Posted by on August 30, 2002 06:37 AM | TrackBack




Comments:


I would add that when drugs go over-the-counter, or even just generic, there is often a certain amount of re-formulation eg adding starch as a base to make a pill look more standardized (think bulking out a nitroglycerin pill to make it the size of an aspirin), which can sometimes be a problem.

At the other side of that, I have often wished Mars would sell some of their older equipment to Pfizer to coat some of the vile-tasting and after-tasting stuff we have to take. 8=P

Posted by: John Anderson on August 31, 2002 12:56 PM






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