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August 21, 2002


More on C-reactive protein

Packed With Promise: Blood Test May Predict Heart Attack Risk

"Unfortunately, most heart attacks and most strokes happen in people who have average cholesterol and not severely elevated blood pressure," Libby said.

Studies show that once it is detected, inflammation can be treated effectively by drugs commonly used to treat high cholesterol, like Lipitor and Zocor, as well as aspirin, exercise and weight loss.

There is much logic here. I have been reading the inflammation hypothesis literature recently. The data are very convincing. We have much indirect evidence that we should address inflammation. We do not have, however, good prospective data on efficacy. Should we test everyone and start more statins? And what dose of statins should we use? Do we then recheck the CRP level to show normalization? I have mixed feelings here. Although, I must confess that if I had a strong family history, I would probably get tested and if positive take a statin. But I still think that I'm playing the odds without clear data.

Posted by on August 21, 2002 05:37 AM | TrackBack




Comments:


"Studies show that once it is detected, inflammation can be treated effectively by drugs commonly used to treat high cholesterol, like Lipitor and Zocor, as well as aspirin, exercise and weight loss."

Gee, despite "normal" cholesterol levels, blood pressure, weight, and so forth the same things pushed on all overweight people and seem to have effect also have effect on people who are not. Think something besides weight may be at work here?

"But I still think that I'm playing the odds without clear data."

Welcome to the club. The medications I take both come with the information that noone knows why they work (lack of clear data) but work they do (playing the odds) so I take them anyway. This is how I feel about the "diet and exercise" mantra - despite years of research, I think it still boils down to "we don't know why it works, but it does, so push it."

Posted by: John Anderson on August 22, 2002 04:32 PM






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It would be nice if everybody could find a doctor with half the common sense of this one. - Junkyardblog

An academic general internist comments on medical issues and the current state of medicine.

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